Sialic acid content and surface hydrophobicity of group B streptococci

Virulent and avirulent strains of group B streptococci from Rio de Janeiro, Brazil: relationship between differences in surface hydrophobicity, sialic acid content and macrophage interaction.

Influence of sialic acid on the surface hydrophobicity of membranes

5-HIAA in the caudate nucleus (Alzheimer, 3.2 f 1.7; control, 5.2k2.3; P< 0.01), HVA in the caudate nucleus (Alzheimer, 13.5k5.0; control, 24.6k7.3; P<O.OI) and HVA in putamen (Alzheimer, 2.3 k0.9; control, 4.7k2.6; P<0.002). The highest CSF concentration of HVA is in the lateral ventricles, which are adjacent to the dopamine-rich caudate nucleus. Therefore, it seems likely that the CSF deficit...

Capsular sialic acid limits C5a production on type III group B streptococci.

The majority of type III group B streptococcus (GBS) human neonatal infections are caused by a genetically related subgroup called III-3. We have proposed that a bacterial enzyme, C5a-ase, contributes to the pathogenesis of neonatal infections with GBS by rapidly inactivating C5a, a potent pro-inflammatory molecule, but many III-3 strains do not express C5a-ase. The amount of C5a produced in se...

Cell surface hydrophobicity and adherence of a strain of group B streptococci during the post-antibiotic effect of penicillin.

The minimum inhibitory concentration and post-antibiotic effects of an antimicrobial agent are parameters to be taken into consideration when determining its dosage schedules. The in vitro post-antibiotic effects on cell surface hydrophobicity and bacterial adherence were examined in one strain of group B streptococci. Exposure of the microorganism for 2 h at 37 degrees C to 1 x MIC of penicill...

Sialic acid-dependent interaction of group B streptococci with influenza virus-infected cells reveals a novel adherence and invasion mechanism.

Group B streptococci (GBS) contain a capsular polysaccharide with side chains terminating in α2,3-linked sialic acids. Because of this linkage type, the sialic acids of GBS are recognised by lectins of immune cells. This interaction results in a dampening of the host immune response and thus promotes immune evasion. As several influenza A viruses (IAV) use α2,3-linked sialic acid as a receptor ...